It is finally the first game week of the 2022 NFL season, a campaign that fans of the Buffalo Bills hope – and expect – will not conclude until February. But before that happens, the Bills have some things to sort out. After three weeks of training camp, Buffalo will get to evaluate itself in live game action on Saturday as it kicks off its preseason against the Indianapolis Colts. Which Bills have the most to prove in the first of three preseason games? Jamison Crowder As I have touched on in an earlier piece, Isaiah McKenzie put some distance between he and Jamison Crowder for the number one slot option on the depth chart while the latter was out of training camp battling injury. That said, Crowder is still the more experienced of the two and has had a far more productive career. With McKenzie out during Monday’s practice, Crowder ran with the ones most of the day, perhaps closing the gap. A strong preseason performance would go a long way in securing a spot at the top of the depth chart. James Cook At this point, there isn’t a ton we are going to learn about Devin Singletary,…