Giants vs. Bills: Top 5 Storylines to Watch in NFL Week 6

The Buffalo Bills need a bounce-back game after the lackluster outing in London on Sunday that ended in a 25-20 loss. The loss dropped Buffalo to 3-2 on the year, but the season isn’t over. The Bills are still second in the league in point differential behind the 49ers. Lucky for them, the next game up is against the Giants, who sit at 1-4 and have a league-worst point differential of -91. The current spread is -14, yes, the Bills are favored to win by two touchdowns. It’s the largest spread of week six. Without further ado, here are my top five storylines to watch as the Bills return from across the pond to host the Giants of New Jersey on Sunday Night Football.